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The naturally occurring SOD has different active center ions, but the catalytically active sites have a high degree of structural identity and evolutionary conservation, that is, the active center ions are a tetragonal pyramid or a tetrahedron composed of 3 or 4 histidine (His), imidazolyl and 1 H 2 O molecule

Another solution when previous options have proven insufficient for pain and disease control is represented by aromatase inhibitors, which locally suppress estrogen synthesis, inducing a hypoestrogenic state

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