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However, reconstitution of Traf6 -/- fibroblasts with TRAF6 C390S was unable to completely rescue P-IB and IFN- mRNA induction in response to HSV-2 and poly(IC) (Figure 5B, C)

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The ER-resident GPx7 or GPx8 isoforms protect -cells of insulin-secreting INS against lipotoxicity by enhancing the antioxidant capacity of ER without compromising insulin production and oxidative protein folding mechanisms [19, 59]