As glutathione levels can decline with age, stress, inflammation, and toxin exposure, targeted supplementation is often utilized within precision wellness programs to help maintain optimal cellular function and internal defense systems
Chemokines, adhesion molecules and other inflammation-related gene promoters all contain nuclear factor NF-B recognition sites
These processes play key roles to promote chemoresistance in tumors, where elevated GSH inactivates electrophilic chemotherapeutic agents (cisplatin, alkylators), GSTs enable drug conjugation, and MRP-catalyzed efflux reduces intracellular drug levels - while inhibiting therapy-induced oxidative stress at the same time
Because NF-B in turn activates many pro-inflammatory cytokines, this mechanism could contribute to increased inflammation and cytokine storms observed in COVID-19
GLOBAL GLUTATHIONE MARKET SIZE, BY NUTRACEUTICAL, BY REGION, 2018-2032 (USD MILLION) TABLE 41