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The San Francisco-based firm is a spinoff of Pax Labs, which is also named in the lawsuit

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TGF-/Smad signaling pathway The transforming growth factor- (TGF-) superfamily consists of a group of distinct polypeptides involved in regulating a wide range of cellular and physiological processes, including proliferation, differentiation, migration, adhesion, ECM synthesis and cell death [98]

This pieceby-piece discovery includes early findings of the evidence of clonal evolution of cancer, the Knudsen two-hit hypothesis progression from benign to malignant growth, discovery of oncogenes and tumor suppressor genes, the somatic mutation theory, the Fearon-Vogelstein multistep colon cancer mutation model, mutator phenotype, and the cancer stem-cell theory

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