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The therapeutic era of peptides began in 1921 with the discovery of insulin, a breakthrough that revolutionized diabetes and helped establish biologic therapies in medicine Since then, peptide hormones like oxytocin and human growth hormone (GH) have entered clinical use, and glucagon-like peptide-1 (GLP-1) receptor agonists such as semaglutide are now widely prescribed for obesity and metabolic diseaseconditions increasingly recognized for their effect on orthopaedic outcomes

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25 mM stock, Stemcell Technologies, USA #72102), 10 M SB-431542 (10 mM stock, Stemcell Technologies, USA #72234) and 10 M XAV-939 (10 mM stock, Stemcell Technologies, USA #72674)]

also known as Akt) signaling pathway activation [76]