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Destabilizing mutations facilitate this initial transition, and the increased rate of conversion to a pathological state likely contributes to the earlier age of onset compared with wild-type TTR amyloidosis

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Skin samples were fixed with 4% paraformaldehyde, embedded in paraffin, and sectioned for H&E, Masson, and immunohistochemical staining

Watts, JM, Minden, MD, Bachiashvili, K, Brunner, AM, Abedin, S, Crossman, T, Zajac, M, Moroz, V, Egger, JL, Tarkar, A, Kremer, BE, Barbash, O, Borthakur, G