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Step 4: Allow initial contact

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Mice expose to positively charged NH 2 -PS negatively charged COOH-PS, and pristine polystyrene PS MPs of two sizes (70 nm and 5 m in diameter) for 28 days respectively, the intestinal barrier was damaged after exposure, and led to significant gut microbiota dysbiosis (Qiao et al., 2021), suggesting that gut microbiota plays a vital role in protecting gut health against MP invasion and that MPs may affect human gut health in the same way