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revealed that legumain deficiency alleviated the development of renal tubular injury and ferroptosis in AKI mice, which proved legumain enhanced renal tubular epithelial cell ferroptosis by facilitating autophagy in AKI(Chen et al., 2021c)

The results demonstrated a very strong accumulation of ROS inside the hypoxic cancer cells upon treatment with NP4 but a poor ROS accumulation upon preincubation with NAC and subsequent treatment with NP4 (flow cytometry plots: Fig

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Consequently, it is predicted that the oxidative DNA damage pathway may become relatively dominant in the bioactivation of toremifene in vivo, potentially contributing more significantly to its overall toxicological profile compared to tamoxifen