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For example, in the case of major depression, the symptoms of anhedonia and behavioral despair have been extensively used in animal studies and possess a degree of face validity for the clinical disorder, whereas the DSM-IV symptoms of guilt and suicidality are virtually impossible to evaluate in an animal (Nestler & Hyman, 2010)

Inflammation and Cellular Signaling Inflammation is a natural part of the bodys response to injury, but excessive or prolonged inflammation can interfere with recovery

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