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In landmark mouse studies, oral 5-amino-1MQ produced robust reductions in adipocyte size, body fat and inflammatory adipokines while leaving food intake unchanged pointing to a fundamentally novel metabolic-rejuvenation mechanism that operates entirely on the methylationNAD axis
By inhibiting NNMT using agents such as 5-amino-1MQ, it's possible to enhance NAD+ levels and activate genes that promote metabolism
Maintain a well-rounded diet focused on protein, healthy fats, and whole-food carbohydrates to support metabolic processes
Kwon and Park 2015 reported that intra-articular AOD-9604 injections, especially when combined with hyaluronic acid, improved cartilage scores and reduced lameness in a rabbit collagenase-induced osteoarthritis model
When NNMT runs too high in fat tissue, it wastes a form of vitamin B3 that the body needs to make NAD+
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