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Melanin pigmentation is a common feature of the oral mucosa

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The C677T variant is linked to decreased arsenic detoxification and increased skin lesions with exposure.[ref][ref] Related article: Arsenic detoxification genes Additionally, methylation is important in detoxifying mercury

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Meyer JH, Kapur S, Eisfeld B, Brown GM, Houle S, DaSilva J, et al

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Mitochondrial-nuclear Heme Trafficking in Budding Yeast Is Regulated by GTPases that Control Mitochondrial Dynamics and ER Contact Sites

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& Arendshorst, W

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