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However, if the fractures are healed without a deformity or only residual minor endplate changes such as Schmorls nodes, it remains difficult to separate these from a developmental or idiopathic degenerative genesis

Patients with Fitzpatrick IV-VI skin should be monitored for potential irritation during initial use, particularly in combination with other actives, and formulations should be pH-controlled (pH 3.5 or lower for efficacy without excessive irritation)