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Furthermore, probiotics help maintain immunological equilibrium by attenuating pathological inflammation through the inhibition of pro-inflammatory cytokine signaling and suppression of the nuclear factor-B (NF-B) pathway (253)

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110 Mechanistic studies have shown that combination therapy induces increased ROS and lipid peroxides and depletion of GSH, and downregulates ferroptosis inhibitory proteins, including FTH1, SLC7A11, GPX4, and FPN, 110 suggesting that -elemene is a novel inducer of ferroptosis