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It stimulates the release of norepinephrine and dopamine by inhibiting the reuptake of these brain chemicals

31,82 Recent work shows that cigarette smoke extract can worsen cartilage degeneration and induce apoptosis, oxidative stress, mitochondrial dysfunction, and matrix abnormalities in OA chondrocytes, while TNF- inhibition may partly reduce these effects

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acetaldehyde, phenol and potassium cianide8, and many of these components are provenly toxic to the respiratory epithelium.9 One of the possible explanations for cigarette smoke participating in the pathophysiology of CR is based on mucociliary transport alterations

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