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The nanosystem exhibited excellent antitumor efficacy and commendable safety on the subcutaneous xenograft nude mice under light irradiation, benefitting from its tumor accumulation ability (Zhang X

Inhibition of system Xc (inhibiting SLC7A11 expression) influences the GSH synthesis, which decreases GPX4 activity and ultimately triggers ferroptosis

The drug contains the active ingredient, ebselen, a synthetic compound that mimics and induces glutathione peroxidase (GPx), an enzyme with anti-inflammatory and antioxidant properties

VFA, visceral fat area

doi: 10.1152/ajpendo.00652.2011 37 WangXWeiZGuMZhuLHaiCDiAet al