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Although smoking-related carcinogens act on both proximal and distal airways inducing all the major forms of lung cancer, cancers arising in never smokers target the distal airways and favour adenocarcinoma histology

However, approximately half of all smokers receiving such treatment are unable to achieve even short-term abstinence, highlighting the need for novel strategies to enhance cessation outcomes 1-4

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Many of the major cigarette manufacturers and other importers representing major tobacco companies imported cigarettes