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Investigations assess its potential effects on cuprizone-associated demyelination, traumatic brain injury, neurotoxin-induced dopaminergic disruption, neurotransmitter regulation, and peripheral or central nerve regeneration

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So there's a homeostatic mechanism that might explain some of these anhedonia side effects that people are reporting

High doses of supplemental B3 (niacin) Additionally, high doses of B6 Another side effect of B-complex supplements is that they can turn your urine bright yellow

Most antibiotics, methotrexate, and pyrimethamine invalidate folic acid and vitamin B12 diagnostic microbiological blood assays