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The antioxidant activity of MCP was revealed in various animal studies including diabetes-associated cognitive impairment ( in vitro model of mouse monocytes ( The master and emerging regulator of cellular antioxidant defense, Nrf2, induces the transcription of antioxidant enzymes and enzymes involved in GSH and NADPH regeneration ( Galectin-3 is pivotal in fibrosis and inflammation ( Galectin-3 was reported as an endogenous paracrine ligand and activator of TLR-4 inducing an inflammatory response ( Recently, the contribution of the TLR-4/NF-B signaling pathway in MTX-induced liver toxicity was documented ( Crosstalk between TLR-4 and oxidative stress has also been reported
The study found that the main urine protein in the urine of CRY/ male mice was reduced compared with that of wild-type mice, which was related to the downregulation of MUP1 gene expression in the liver
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