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Further mechanistic studies suggest that the cardioprotective effects of APS may be mediated by the regulation of the PI3K/Akt/mTOR signaling pathway, which is essential for maintaining cardiomyocyte survival, regulating autophagy, and inhibiting apoptosis (Luo et al., 2014)

Pharma-grade encapsulated nutrients through liposomal technology take nutraceutical products to newer levels [9]

The trade-off is higher cost and the requirement for clinical administration

On the other hand, AMPK can phosphorylate GAPDH which, once phosphorylated, is translocated to the nucleus where is able to inhibit DBC1, an SIRT1 endogenous inhibitor, increasing activated SIRT1 levels

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