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The TME significantly impacts melanomas transcriptomic landscape, meaning nano-immunotherapy not only induces tumor cell death but may also drive shifts in melanoma cell states and meta-programs (51)

It has long been known that a variety of sources of hydrogen peroxide production via enzymatic and non-enzymatic reactions exist and their successful elimination is carried out by glutathione peroxidase (GPX), catalase, and peroxiredoxin (PRDX)

[DOI] [PubMed] [Google Scholar] 26.Decramer M., Rutten-van Mlken M., Dekhuijzen P.N., Troosters T., van Herwaarden C., Pellegrino R., van Schayck C.P., Olivieri D., Del Donno M., De Backer W., Lankhorst I., Ardia A

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