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For example, acetyl-CoA serves as a critical precursor substrate for the de novo synthesis of fatty acids mediated by cytosolic fatty acid synthase (FASN), known to be a central factor underlying the survival, uncontrolled proliferation and progression of numerous types of cancer cells 67,68

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The first clinical study was carried out on ethacrynic acid, an approved diuretic drug that nonspecifically inhibits GST, GST, and GST isoforms [92]

An AusPAR is also publicly available, outlining their decision-making process and rationale [36]

found that restoring histological abnormalities in ovarian and breast cancer rat models decreased serum MMP-1, NF-B, and TNF- levels (El-Beltagy et al., 2021)