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A: Most users report 48 weeks for noticeable changes

The minimal direct evidence currently available is consistent with this and indicates that Nrf2 may be critical for protection against ferroptosis

J.et al (2022a)

In addition, the multifunctional FN III9-10/12-14 greatly enhanced the regenerative effects of BMP-2 and PDGF-BB in a rat critical-size bone defect model [186]