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it also damages blood vessels, stiffens arteries, and increases your long-term risk of heart disease or your chances of a heart attack or stroke

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The dysregulation of nitric oxide synthase and decoupling of endothelial nitric oxide synthase (eNOS) eventually lead to endothelial dysfunction, which is considered the pathological basis of atherosclerosis, hypertension, and cardiomyopathy [101]