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Additionally, SASP inhibits the amino acid transporter xCT, which reduced intracellular GSH levels, diminishes cellular antioxidant defense and induces ferroptosis in cancer cells (74)

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2.3.2 Stress response and signaling PSMs are often upregulated in response to pesticide-induced stress, acting as antioxidants and signaling molecules that trigger broader defense responses, including the activation of detoxification pathways (Zhang and Yang, 2021

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In the human body, the major intracellular derivative of thiamine is its diphosphorylated form, thiamine diphosphate (ThDP)