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Evans and Lake 1998)

IGF-1 exerts protective effects over mitochondria by preserving it from the oxidative damage generated by augmented metabolism, and increasing ATP synthesis and reducing intramitochondrial production of free radicals [105107]

Therefore, it was pertinent to evaluate the cholesterol-lowering potential of indigenous probiotic both in vitro and in vivo by systematically analyzing the anthropometric parameters, serum lipid profiling, oxidative stress biomarkers, and aortic histopathology in an experimental Sprague Dawley (SD) rat fed with high-cholesterol diet (HCD)

World J Gastroenterol 12(34):5501-5508, 2006