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3.4 Clinically successful multi-targeted agents with pleiotropic antioxidant effects Beyond strategies primarily focused on directly modulating oxidative stress or its immediate downstream consequences, certain established or emerging cardioprotective agents have demonstrated clinical success in MIRI, at least in part, through mechanisms that involve mitigating oxidative stress alongside other pathways

This protective function is particularly significant as oxidative stress can inhibit cell growth, and the combination of vitamin E with carotenoids prevents the growth inhibition typically caused by increased melanin production 178

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