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Many individuals absorb B12 poorly from food or pills due to low intrinsic factor or other gastrointestinal limitations

The DNMT1 protein faithfully maintains the pattern of methylated CGs that would otherwise become lost through cell divisions, whereas the de novo methyltransferases, DNMT3a/b, can also catalyze non-CG methylation (Suetake et al., 2003

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Angiopep-2 conjugation enabled receptor-mediated BBB transport, enhanced uptake, prolonged circulation, and improved glioma targeting, making ANG-LP-PAA-MSN@ATO a promising nanotherapeutic for glioma