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Given the muscle weakness that is part of the prime disturbance, vascular failure [66,71,72,73,74,75,76,77,78,79,80,81,82], stroke [20], traumatic brain injury [21], spinal cord compression [28,29], vessel occlusion and similar noxious procedures [66,71,72,73,74,75,76,77,78,79,80,81,82] were all specifically highlighted in the literature

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They can act as signaling molecules such as hormones or neurotransmitters in many organisms, and they are also present in other biological compounds like antibiotics, which interact with biological systems in complex ways

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