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The ASM is activated by several cellular stresses implicated in both apoptosis and autophagy by modulating the balance between ceramide and its metabolic derivatives, sphingosine (Sph) and sphingosine-1-phosphate (S1P) (Figure 2)

Redox signaling in macrophages

Proteome alterations in leaves of A

Together with the other reports measuring less FDG uptake or a decline in intratumoral lactate levels as summarized in Table 2, this implies that a KD is able to influence tumor cell metabolism by lowering insulin levels and increasing ketone body concentrations

Statistical analysis involved counting changes in fissures and average neuron density observed in individual brain sections analyzed per microscopy field