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New basic and clinical research is clarifying the mechanistic relevance and therapeutic feasibility of multiple targets within the glutamate system for novel drug discovery, including NMDA and AMPA (-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) receptors, metabotropic glutamate receptors, and other key regulatory proteins such as glycine transporter 1 and excitatory amino acid transporters

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One such gene is MALAT1, a long non-coding RNA located on chromosome 11q13.1 initially discovered in NSCLC, which also plays a regulatory role in vascular biology