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Manufacturers can be responsible for poor design, insufficient product testing and overall poor quality control measures

Cancer Detection and Prevention, 15(5):331-334

Lawlor DA, Harbord RM, Sterne JAC, Timpson N, Smith GD (2008) Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology

Notably, tobacco smoking represents a significant promoting factor in TB progression, being associated with poorer treatment outcomes, delayed conversion to negative smear or culture, and higher dropout rates from treatment plans

As retailers continually look to balance premium offerings with value-driven products in a high-pressure economic environment, fourth-tier cigarettes can offer an avenue for boosting sales, Brinkley noted