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These proteins form what is called an apoptotic blockade, meaning that cells cannot undergo apoptosis, even when they experience DNA damage that would normally trigger cell death

The compound (+)-anthrabenzoxocinone inhibits PI3K/AKT/mTOR signaling, inducing cell cycle arrest, apoptosis and autophagy, while elevating reactive oxygen species (ROS) in NSCLC cells (43)

NPJ Aging 10 , 7 (2024)

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Compound Dataset Preparation A library containing a consolidated list of 5,30,881 drug like compounds from Asinex and 1,32,883 natural products from ZINC was prepared and used for virtual screening