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They were given either 1980 milligrams of L-carnitine per day (taken as 990 mg twice daily as has been used in previous studies (11, 12) = 28 subjects) or a placebo (25 subjects) for 12 weeks

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This engineering was necessary to reduce the proliferative effect of native FGF19 on hepatocytes, mediated via signaling through FGFR4the only FGF receptor at which FGF19 and FGF21 differ in agonist activity (305)

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