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In a 36-week paired liver biopsy study (NCT02912260), markers of fibrosis were reduced significantly by Resmetirom treatment, including the reductions in LS ( p = 0.015) and the ratio of PRO-C3 (N-terminal type III collagen pro-peptide)/C3M (metalloproteinase-degraded collagen III) ( p = 0.0004), a proposed measure of net fibrosis formation, in adult patients with NASH

Keiichiro Nishida et al