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In another study, GBs protective effect on melanocytes was shown to be dependent on activation of the Nrf-ARE pathway and downstream antioxidant genes, including NQO-1, SOD2 and haem oxygenase-1 [107]

95% CI 0.792.43, p for trend 0.37), however, the 95% CI of the point estimate included the null-effect value

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If you have additional risk factors (PCOS with 50% lower glutathione, IVF with 70-83% depleted antioxidants, gallbladder issues, choline deficiency), your effective "safe" dose may be significantly lower