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However, mitochondrial ETC is the main cellular process of ROS generation in most cell types in physiological circumstances (Venditti et al., 2013)

(PubMed) Heude B, Ducimetiere P, Berr C

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Many studies indicate that environmental enrichment based on cognitive, sensory, and motor stimulation induces neuron remodelling and enhances cognitive and physical performance in animal models of AD, PD, ALS, and HD [203]