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The condition typically develops gradually, starting as mild stiffness that resolves with warmup, then progressing to persistent pain that limits training capacity

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It may also appear in form of breathing trouble, dizziness, or swelling

[4] Red flag symptoms requiring immediate medical assessment include: progressive or worsening neurological symptoms, changes in vision, significant gait disturbance, or cognitive decline

These changes occurred through direct effects on adipocyte biology rather than appetite suppression, as research models maintained normal feeding behavior while exhibiting significant reductions in individual adipocyte size