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Findings support the scales content validity and its suitability as a clinically meaningful outcome measure for future trials in this population

Nicotinamide (niacinamide) does not cause flushing and has fewer side effects, with nausea and liver toxicity reported only at very high intakes ~3 g/day)

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The exchange-functional is treated using the generalized gradient approximation (GGA) with Perdew-Burke-Ernzerhof (PBE) functional