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However, it is not clear what contributed specifically to this effect on inflammation, though increasing evidence suggests that IGF-1 signaling is critical for maintaining immune cell homeostasis 44 , but the prospects of sex differences in the requirement for IGF-1 signaling in these cells is not yet known and will require further study

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Nat Rev Drug Discov 20 , 362383 (2021)

10.1111/apha.13572 18 BalligandJ

Application of the Revised Lung Cancer Staging System (IASLC Staging Project) to a Cancer Center Population