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The composition of the PC critically affects the interaction with the macrophage, and a recent proteomic study has shown that its composition depends more on the origin of the biological fluid (animal species) than on the coating of the particle (169)

In contrast to the present findings in humans with compensated liver cirrhosis, some animal studies did provide evidence of oxidative stress in the small and large intestine of rats with carbon tetrachloride (CCl4)-induced liver cirrhosis, although part of them had ascites.13,2426 Published data on the occurrence of intestinal oxidative stress in cirrhotic patients are scarce

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