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The Coronaviridae family of positive-stranded RNA viruses contains three subfamilies, including the Orthocoronavirinae subfamily, to which SARS-CoV-2 belongs

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In naturally aged mice, FOXO4-DRI improved the testicular microenvironment and alleviated age-related testosterone secretion insufficiency with decreased p53, p21, and p16 protein levels in treated testes compared to aged controls

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