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Moreover, aging increases the vulnerability of the BBB to disruptive substances [55, 275, 276], and age-associated conditions like hypertension [277, 278] and cerebral ischemia [279, 280] alter the BBB

The proportion of p--syn in the normal state is very low, and an abnormal increase in p--syn induces the formation of pathological aggregates that contribute to neurotoxicity [10]

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Nrf2 improves endothelial function by resisting oxidative stress and mitochondrial damage, thereby delaying atherosclerosis (245)

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