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Excessive free radicals are associated with many diseases: atherosclerosis, cataracts, cancer, Alzheimers, osteoarthritis, immune dysfunction, and more
Among them, the most typical is the chemokine Leukotriene B4 (LTB4), the increased expression of which causes recruitment of neutrophils, ATMs, T cells, and B cells, which increase expression of pro-inflammatory cytokines, eventually leading to the development of eWAT inflammation and obesity (132) ( Figure 3 )
While IBB scale is more detailed and adjusted for fine motoric impairment due to cervical spinal cord injury, our modified and simpler scale reflects impairment due to cuprizone induced central nervous system injury
Brain Sci 13(10):1475 Wray NR, Lee SH, Mehta D et al (2014) Research Review: Polygenic methods and their application to psychiatric traits