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10.1016/j.jsmc.2015.08.002 76 EdisonP

Topical peptides function as signaling molecules that communicate with fibroblasts and keratinocytes, stimulating: Collagen synthesis (types I, III, and IV) Elastin production Barrier repair and hydration retention Melanogenesis regulation (relevant to hyperpigmentation research) Key peptide classes studied in dermatology include: Peptide Class Example Primary Function Signal Peptides Palmitoyl Pentapeptide-4 (Matrixyl) Stimulates collagen and elastin production

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It remains an unapproved, investigational substance, with a federal advisory committee due to reassess it in mid-2026