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Biomedicines 8 , 129 (2020)

GSH synthesis using the whole-cell biocatalyst was performed in 0.2 M phosphate buffer (pH 7.0) containing 40 mM l-glutamate, 20 mM l-cysteine, 40 mM glycine, 20 mM MgCl 2 and 20 mM ATP

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MeNAM can be excreted in the urine or is further oxidized into N-methyl-6-pyridone 3-carboxamide (me-6PY or 2PY) or N-methyl-4-pyridone 3-carboxamide (me-4PY or 4PY) 58

Typical onset of phosgene-induced symptoms occurs 2 to 6 hours after exposure and delayed symptoms have been described up to 15 hours post exposure