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Cullin RING ligase 5 (CRL-5): neddylation activation and biological functions

doi: 10.1097/01.mbc.0000214705.80997.73 353 PretoriusEMbotweSBesterJRobinsonCJKellDB

Reactive astrocytosis is a consistent pathological hallmark not only in AD, but also in PD, ischemic stroke, and ALS

Retatrutide , developed by Eli Lilly, is a novel triple agonist that simultaneously activates three receptors: GLP-1 (glucagon-like peptide-1) receptor reduces appetite and slows gastric emptying GIP (glucose-dependent insulinotropic polypeptide) receptor enhances insulin secretion

Despite these exciting results, some caveats for interpretation of this study should be mentioned