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Exercise regularly, but not excessively: Moderate aerobic exercise stimulates glutathione production, while chronic overtraining can deplete it

Autophagy can be induced by nutrient deprivation, which activates AMPK (a sensor of energy depletion) and inhibits mammalian target of rapamycin (mTOR, an autophagy suppressor), as well as oxidative stress, hypoxia, exercise, drugs (rapamycin, metformin) and hormones (glucagon)

doi:10.1007/BF02785352

10.1371/journal.pone.0280136 101 SibomanaI.FooseD

Cellular Defence GSH contributes to the response to oxidative and electrophilic stress, but the relationship is not simply that more is always better