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Despite these advances, it is imperative to recognize the limitations encountered in clinical trials of anti-inflammatory medications aimed at vascular inflammation

Taking medication or supplements can also make a difference

Without offering a citation for a published paper or sharing any data, Sikirics 2025 review states that this clinical trial found that the drug was safe and well-tolerated in humans

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Nonetheless, NAPQI binding to mitochondrial proteins correlates with APAP toxicity30, and hence the effect could be a cumulative one, with mitochondrial function being affected once a threshold of mitochondrial protein modification is attained