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This usually results in larger-than-normal red blood cells that are unable to move from the bone marrow into the bloodstream at an appropriate rate (R)

When NNMT activity is reduced, less nicotinamide is methylated and wasted, allowing NAD pools to remain higher

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In these conditions, bowel thickening and inflammation leads to poor absorption of nutrients and weight loss

No serious adverse events were attributed to AOD-9604 across the entire clinical trial program involving over 900 participants