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For inaccessible tumors, imaging-guided or surgical approaches are required, which further complicate intratumoral injection

Match vial size to protocol duration to minimize waste: 2mg for studies under three weeks, 5mg for studies lasting 35 weeks, and 10mg only for multi-subject or extended-duration protocols

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Currently, there are 4 active interventional studies for SCAs that include SCA3 patients: 2 with drugs (troriluzole and BHV-4157, a prodrug of riluzole

Long term biweekly 1 mg oral vitamin B12 ensures normal hematological parameters, but does not correct all other markers of vitamin B12 deficiency